It followed Sam and Dean Winchester who grew up hunting monsters after the unexplained death of their mother, and carry on the legacy when their father goes missing.
By no means is Supernatural a niche show, having ran way past it's expected time, stopping at the fifteenth season with an accumulated 327 episodes (an average of 23 per season). The show had gotten a one-season anime series1 and a few Comics2 & Novels3
The popularity grew primarily on tumblr, but it did have a pretty big impact, having been referenced in other shows4.
[1] - Supernatural: The Animation can be rented on prime or on Facebook.
[2] - Published by DC, available on their website with an account or by pirating.
[3] - There's 17 books published by HarperEntertainment. Probably available at your local library:) also on Amazon.
[4] - Lucifer, The Boys, Walker, Legends of Tomorrow, MAD, etc.
Information taken & paraphrased from the Wikipedia page, Supernatural Wiki page, and the Fandom Wiki page.